Bacterial infections due to ofloxacin susceptible microorganisms, such as

- acute, chronic, or recurrent lower respiratory tract infections (bronchitis), especially if caused by Haemophilus influenzae or other Gram-negative or multi-resistant pathogens, as well as by Staphylococcus aureus.
- pneumonia, especially if caused by problem pathogens such as Escherichia coli, Klebsiella, Enterobacter, Proteus, Pseudomonas, Legionella, or Staphylococcus. Since in outpatients pneumococci are the most frequent pathogens responsible for pneumonia, OFLOXOL is not the treatment of first choice in these patients.
- chronic and recurrent infections of the ear, nose, and throat, especially if caused by Gram-negative pathogens including Pseudomonas, or by Staphylococcus.However,OFLOXOL is in general not indicated for the treatment of acute tonsillitis caused by beta haemolytic streptococci
- infections of soft tissues and skin.
- infections of the bones and joints.
- abdominal infections including infections in the pelvis minor and bacterial enteritis.
- infections of the kidney, urinary tract, and genital organs, gonorrhoea.
- septicaemia (blood poisoning).

Antibacterial spectrum
The following microorganisms may be regarded as susceptible:
Staphylococcus aureus (incl. methicillinresistant staph.), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Hafnia, Proteus (indole-negative and indolepositive strains), Salmonella, Shigella, Yersinia enterocolitica, Campylobacter jejuni, Aeromonas, Plesiomonas, Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydiae, Legionella.
The following microorganisms vary in their susceptibility:
Enterococci, Streptococcus pyogenes, Streptococcus pneumoniae,
Streptococcus viridans, Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis, Mycoplasma pneumoniae, Myco-bacterium tuberculosis, and Mycobacterium fortuitum.
The following microorganisms are usually resistant to ofloxacin:
Ureaplasma urealyticum, Nocardia asteroides, anaerobes (e.g. Bacteroides spp., Peptococcus, Peptostreptococcus, Eubacterium spp., Fusobacterium spp., Clostridium difficile). Ofloxacin is not effective against Treponema pallidum.